Tag: CTLA-4
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BioNTech’s Gotistobart Posts 18.5-Month Median Survival in Squamous NSCLC
Gotistobart achieved median overall survival of 18.5 months versus 10.0 months with docetaxel in the non-pivotal stage 1 portion of PRESERVE-003.
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How Gotistobart Preserves CTLA-4 Recycling
Gotistobart uses pH-sensitive CTLA-4 binding to preserve receptor recycling, differentiating its intracellular trafficking from conventional pH-insensitive anti-CTLA-4 antibodies.