Tag: molecular oncology
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How Jideytro Blocks ROS1 Fusion Signaling in Lung Cancer
Jideytro is a brain-penetrant, TRK-sparing macrocyclic inhibitor designed to block ROS1 fusion signaling and resistant variants such as G2032R.
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How Hyrnuo Blocks Mutant HER2 Signaling in Lung Cancer
Activating HER2 mutations can sustain RAS–ERK and PI3K–AKT signaling in lung cancer. This explainer examines how Hyrnuo reversibly inhibits mutant HER2 kinase activity while limiting wild-type EGFR inhibition.